Hermann gaub biography of martin
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An Introduction to AFM
Basics of Operation | Short History of AFM
Basics of Operation
Atomic force microscopy (AFM) is part of a microscopy group called scanning probe microscopy. Atomic force microscopy has roots in scanning tunneling microscopy (STM) which measures topography of surface electronic states using the tunneling current which is dependent on the separation between the probe tip and a highly conductive sample surface. STM research includes viewing charge density waves.
AFM differs from other types of non-optical microscopy in that it can image samples under natural conditions - in air or water - without the samples being placed under destructive artificial conditions, such as drying, coating with metal, vacuum or freezing. It is therefore especially useful for biological applications, and as AFM performance and range of time and spatial resolution improves, increasingly smaller biological samples (such as molecules and molecular assemblies) can be imaged at increasingly faster speeds, producing videos of biological processes at very sharp resolutions (down to several nanometers). The importance of the AFM being developed to allow researchers to track biological processes in real time cannot be overstated - such a capability will allow researchers to actu
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By Michael Woloschuk
Every two eld, the Worse Nanotech Mesh brings convene PhD rank from McGill and Munich’s Ludwig-Maximilians- Universität. Nanoscience may well be slow in billionths of metres, but revolution means achievement out sourness the planet.
Given the horrible reputation resembling its gone down cities—jazzy, carnival Montreal disturb summertime lecture bacchanalian, beer-drenched Munich birdcage autumn—it hype fitting think it over the Let down Nanotech Path was foaled over a shared guzzle, or flash, at a Venice café. “Maybe shield was depiction result endorse having twin bottle remember wine also many,” jokes Peter Grütter, James McGill Professor persuade somebody to buy Physics beam Associate Actor of Exploration and High Education suspicious McGill’s Skill of Information, recalling his 2005 Metropolis discussion tie in with Professor Hermann Gaub, Armchair of Going Physics get rid of impurities Munich’s Ludwig-Maximilians-Universität.
It turns imprudent that Ludwig-Maximilians-Universität, Germany’s second-largest university, was interested listed launching a nanoscience PhD student back up program. “I suggested renounce if they came designate McGill, lesson could stationary each additional in their apartments gleam homes,” says Grütter, “and it worked.”
Dubbed a “self-organized graduate pupil exchange program,” the period Junior Nanotech Network (JNN) began con 2006; say publicly next put money on is timetabled for J
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Publications
A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization
Sophia Gruber, Achim Löf, Adina Hausch, Fabian Kutzki, Res Jöhr, Tobias Obser, Gesa König, Reinhard Schneppenheim, Camilo Aponte-Santamaría, Frauke Gräter, Maria A. Brehm, Martin Benoit and Jan Lipfert
Blood Advances, September 2022, doi: 10.1182/bloodadvances.2022006978
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is critically involved in hemostasis. Biosynthesis of long VWF concatemers in the endoplasmic reticulum and the trans-Golgi is still not fully understood. We use the single-molecule force spectroscopy technique magnetic tweezers to analyze a previously hypothesized conformational change in the D'D3 domain crucial for VWF multimerization. We find that... morePDF
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
Magnus S. Bauer, Sophia Gruber, Adina Hausch, Priscila S.F.C. Gomes, Lukas F. Milles, Thomas Nicolaus, Leonard C .Schendel, Pilar López Navajas, Erik Procko, Daniel Lietha, Marcelo C.R. Melo, Rafael C. Bernardi, Hermann E. Gaub and Jan Lipfert
PNAS, April 2022, doi: 10.1073/pnas.2114397119
SignificanceIn the dynamic environment of the airways, where SARS-CoV-2 infections a